FGF-23 Regulates CYP27B1 Transcription in the Kidney and in Extra-Renal Tissues
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FGF-23 Regulates CYP27B1 Transcription in the Kidney and in Extra-Renal Tissues
The mitochondrial enzyme 25-hydroxyvitamin D 1α-hydroxylase, which is encoded by the CYP27B1 gene, converts 25OHD to the biological active form of vitamin D, 1,25-dihydroxyvitamin D (1,25(OH)2D). Renal 1α-hydroxylase activity is the principal determinant of the circulating 1,25(OH)2D concentration and enzyme activity is tightly regulated by several factors. Fibroblast growth factor-23 (FGF-23) ...
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Fibroblast growth factor 23 (FGF-23) is a potent regulator of serum phosphate level. In CKD, circulating FGF-23 levels gradually increase with declining renal function. Higher FGF-23 level was associated with higher atherosclerosis score. We aimed to study the correlation between FGF-23 and the parameters that have effects on morbidity and mortality in CKD patients and to establish its role as ...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2013
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0072816